Metabolite- protein interaction (MPI) network analysis of obsessive- compulsive disorder (OCD) from reported metabolites
Mona Zamanian Azodi · Arvand Journal of Health and Medical Sciences · 2016
Obsessive-Compulsive Disorder (OCD) is a lifetime mental condition with the prevalence of 1-3% in general population. Molecular evaluation of OCD is prominent to understand the complex basis of underlying mechanisms. Here, by the application of MPI construction of significant changed metabolites in OCD patients, it is tried to obtain a preliminarily insight of related molecular interactions. These interactions are fundamental for cell processes and drug design. For this purpose, a number of ten OCD related metabolites were obtained from literature, by the use of PubMed and Google Scholar Resources. Then, the ten candidate metabolites were examined by the application of STITCH 4.0 Online Resource, for investigating the ten significant linked proteins with our query metabolites and the related BPs. Top ten scored interacting proteins with the query metabolites were retrieved and the action types were identified. Some of the protein partners were previously detected as potential polymorphisms in OCD etiology. The Regulation of hormone secretion and regulation of phosphorylation are the most significant (corrected p value< 0.05) related biological process of the ten investigated metabolites in the whole network. The result suggests that, insulin may be influenced significantly in OCD profile as it is significantly regulated by the six of our metabolites in the whole network. In fact, either metabolites or proteins changes may influence each other levels and promotes OCD risk. Thus, further systematic analysis is suggested for confirmation and introduction of new biomarkers.