The delineation of nuclear boundaries in microscopic images.
Robert Thomas Jagoe, Christopher Sowter · PubMed · 1986
A semiautomatic procedure for tracking the boundaries of liver nuclei in digitized microscopic images of normally prepared biopsy material is described. The operator selects the nucleus, and a guided sequential search procedure tracks edge segments, which may subsequently be linked to produce a closed or partially open boundary, which is then accepted, completed or rejected by the user.