Nearest-Neighbor Analysis
Bernard H. Ramsahoye · Humana Press eBooks · 2003
Nearest-neighbor analysis can be used to identify the 3′ nearest neighbors of 5mC residues in DNA ( 1 , 2 ). It can also be used to measure the level of methylation of a specific methylated dinucleotide in DNA. Typically, in the case of mammalian DNA, this means quantifying the degree of methylation at CpG dinucleotides. It has the added advantage of being applicable to small samples of the order of 1 microgram of genomic DNA. The only drawback is that it is a radioactive technique and the appropriate facilities and techniques for handling radioactive substances must be available. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.