Computer Aided Multi-target Drug Design, Multi-target Virtual Screening
Hua Xiao, Zhe Shi, Chunyan Tan, Yuyang Jiang, Mei‐Lin Go, Boon Chuan Low, Yu Chen · 2010
Multi-target drugs against selective multiple targets improve therapeutic efficacy, safety and resistance profiles by collective regulations of a primary therapeutic target together with compensatory elements and resistance activities. Efforts have been made to employ in-silico methods for facilitating the search and design of selective multi-target agents. These methods have shown promising potential in facilitating drug discovery directed at selective multiple targets.