Computational Strategies and Challenges for Targeting Protein–Protein Interactions with Small Molecules
Daniela Grimme, Domingo González-Ruiz, Holger Gohlke · Royal Society of Chemistry eBooks · 2012
In biological systems, function and malfunction ultimately originates from interacting rather than isolated molecules. As such, most cellular processes are carried out by multiprotein complexes,1 and the organization of the ensemble of expressed proteins into functional units results in complex prot...