A chemical–biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives
Fabian Alexander Grimm, Yasuhiro Iwata, Oksana Sirenko, Grace A. Chappell, Fred A. Wright, David M. Reif, John C. Braisted, David Lee Gerhold, Joanne M. Yeakley, Peter J. Shepard, Bruce E. Seligmann, Tim A. Roy, Peter J. Boogaard, Hans B. Ketelslegers, Arlean M. Rohde, Ivan Rusyn · Green Chemistry · 2016
screening approaches can be effectively utilized in combination with physico-chemical characteristics to group complex substances and enable read-across. This approach allows for rapid and scientifically-informed evaluation of health impacts of both existing substances and their chemical alternatives.