Chemoenzymatic Synthesis of δ‐Keto β‐Hydroxy Esters as Useful Intermediates for Preparing Statins
Stefano Tartaggia, Stefano Fogal, Riccardo Motterle, Clark Ferrari, Marta Pontini, Roberto Aureli, Ottorino De Lucchi · European Journal of Organic Chemistry · 2016
Enantiopure (R)‐3‐hydroxy‐5‐oxohexanoic acid esters have proven to be useful intermediates in the synthesis of the side chain of statins, in view of the recently described preparation of rosuvastatin and other statins through aldol reactions. Herein, an improved synthesis of these intermediates, by combining chemical and enzymatic reactions, is described. In particular, the selective reduction of a δ‐ketal β‐keto ester was identified as a key step to obtain derivatives with satisfactory optical purities for use in the synthesis of statins.