The computer-assisted morphological classification of acute leukemia. I. Preliminary results.
Necheles Tf, Brenner Jf, R Fristensky, Neurath Pw · PubMed · 1976
The morphology of leukemic lymphoblasts, as seen in the initial routine bone marrow aspirate, of 40 children with ALL has been evaluated using a computer-assisted automated microscope. A statistic, derived from a combination of the number of macrolymphoblasts and the percentage of cells with no cytoplasm was found to predict response to standard therapy and to identify patients with a high probability of long-term remission as well as a group with a relatively poor response to therapy.