Discovering Protein Clusters
Susan L. Epstein, Xingjian Li, Peter Valdez, Sofia Grayevsky, Eric Osisek, Yun Xi, Lei Xie · 2012
As biological data about genes and their interactions proliferates, scientists have the opportunity to identify sets of proteins whose interactions make them worthy of further investigation. This paper reports on a knowledge discovery technique to support that work. Foretell is an algorithm originally designed to support search for solutions to constraint satisfaction problems. Recent adaptations enable Foretell to detect sets of genes that interact heavily with one another. We provide empirical results, and describe ongoing work on biological meaning and knowledge infusion from the user.