The Strain of Mouse and Assay Conditions Influence Whether MulFN- γ Primes or Activates Macrophages for Tumor Cell Killing
Judith L. Pace, Luigi Varesio, Stephen W. Russell, Elisabetta Blasi · Journal of Leukocyte Biology · 1985
Investigators from two different laboratories have compared several variables in the short-term macrophage-mediated cytotoxicity assays used by each group to study the role of MuIFN-gamma in macrophage activation. The findings suggest that the capacity of MuIFN-gamma to activate macrophages without the need for a second triggering stimulus is related to assay conditions and, most especially, the strain of mouse used to provide the macrophages.