[The Ising model for the description of allosteric kinetics of polymeric enzymes].
D A Cherepanov · PubMed · 1987
A new class of models for the description of the complex allosteric kinetics of oligomeric enzymes has been offered. Its regulation can be realized at the expense of two types of the cooperative interactions. First, the cooperative interaction of the neighboring enzyme protomers is examined on the basis of one-dimensional Ising model; second, subunits that compose the protomer are described by analogy with the model of indirect cooperation of Monod--Wyman--Changeux. The methods of statistical physics open approach to the unification of the models of allosteric regulation in the modern biochemistry. A detailed analysis of the one-ligand model of the polymeric enzymes was performed and possible ways of its generalization were shown.