Expanding the Target Space: Druggability Assessments
Peter Schmidtke, Daniel Álvarez-García, Jesús Seco, Xavier Barril · Royal Society of Chemistry eBooks · 2012
In recent decades, drug discovery has mainly followed a target-based approach, where relationships are sought between a pathological situation and the biological activity of individual macromolecules. Once such a link is established (and confirmed at the target validation stage)1 the goal of drug di...