Signal conduction pathways mediated by insulin receptor and insulin resistance treatment
GS Second · Zhongguo zuzhi gongcheng yanjiu yu linchuang kangfu · 2007
AIM: To investigate the relationship between signal conduction pathways mediated by insulin receptor and insulin resistance (IR), and review the drug treatment for IR. METHODS: The literatures included by Medline database in foreign languages and the related literatures published in domestic core journals were selected, analyzed, classified and summarized. RESULTS: The main reasons of IR include some damaged key molecules in the signal transmission, such as insulin receptor, insulin receptor substrate, phosphatidylinositol 3-kinase and glucose transferor-4. α-glucosidase inhibitors, metformin and thiazolidinediones can rectify the obstacles of insulin signal conduction pathway, and increase the sensitivity of the target tissues to the insulin, which all can improve and treat IR. CONCLUSION: Any damage of insulin signal conduction pathway may lead to IR, and the IR improvement develops to the new drug treatment for insulin conduction medicated by insulin receptor.