Progresses of discovery toxicology research
Liao Ming-yang · Chinese New Drugs Journal · 2005
Discovery toxicology, also named predevelopmental toxicology, is to screen toxicities of new chemical entities (NCEs) in the discovery phase of new drug research,to discover and eliminate the compounds that are unsuitable for further development due to their toxicity as early as possible,and to optimize the next more safe compounds. Discovery toxicology research can break through the limitation and improve the efficiency of drug research. This article will present the concept of discovery toxicology, the essentiality of discovery toxicology research. The content, methods and current status of discovery toxicology in China are described too.