Application of AgNOR Classifying and Its Diagnostic Value for Breast Fine Needle Aspiration Cytology
Pla Fuzhou · 1996
76 pieces of smears of the breast fine needle aspiration cell have been classified and counted for AgNOR.There were 12 cases of benign lesions and 64 cases of malignant lesions among them. The staining and Count were done as usual. The classification was analyzed in according to the self-drafting standard of 3-parameter-judgement which referred to Meehan's method. The result shows that as AgNOR count,the average integral value of the benign lesions is 3.93±0.46,and of malignant lesins is 9.18±2.12.the difference bstween the two values is very obvious(P0.001). The critical value best suitable to diagnosis is 4.7; as AgNOR classifying, the above value is 3.03±0.46 and 6.03±0.76 respectively,the difference between the two values is very obvious, too (P0.001). The critical value best suitable for diagnosis is 4.1.In addition,three parameters for classification were integrated over respectively and all of the results are of significance in statistics (P0.001). AgNOR classification is a simple,fast and repeatable method of count because this technique is easy to handle and the repeatability is high in cases and the diagnostic accuracy is up to 90%. AgNOR classifying is a kind of measurement with multiparameter,so its result has practical value,and is more helpful if combined with the che ck of cytology.