Therapeutic effect of 6-[4-(4′-pyridyl) aminophenyl]-4,5-dihydro-3(2H)-pyridazinone on hemorrhagic shock and its mechanisms in rabbits and rats
Qi Jiang · Zhongguo yaolixue yu dulixue zazhi · 2002
AIM To explore the therapeutic effects of 6-[4-(4′-pyridyl) aminophenyl]-4,5-dihydro-3(2H)-pyridazinone (MCI-154), a novel calcium sensitizer for cardiac contraction, on hemorrhagic shock and its mechanism. METHODS The hemorrhage shock was established by bloodletting from femoral artery and keeping mean artery pressure at 5.33 kPa for 2 h, then normal saline (NS) or MCI-154 (0.2 mg·kg -1 for rabbits, 2.5 mg·kg -1 for rats) was given iv. The survival rate of rats at 12, 24 and 48 h, and heart′s ejection fraction(EF), stroke volume(SV), vascular resistance index(RI), blood flow volume of liver artery, mesentery artery and right kidney artery of rabbits were examinated by colorful Doppler. RESULTS The survival rate of rats in MCI-154 and NS groups at 12, 24 and 48 h was 17/20, 15/20, 13/20 , and 11/20, 8/20, 4/20, respectively. In hemorrhagic shock rabbits, MCI-154 decreased remarkably RI of kidney and liver arteries at 2 h after treatment, and increased significantly EF, SV, blood volume of mesentery artery and kindey artery, meanwhile decreased RI of liver artery at 4 h after treatment. CONCLUSION MCI-154 has satisfied therapeutic effect on hemorrhagic shock, which maybe related to its positive inotropic effect for cardiac function and increasing blood flow volume.