The application of the Computer Aided Drug Design in drugs synthesis
Li Lv · Qilu Pharmaceutical Affairs · 2008
The method of Computer Aided Drug Design(CADD) was the basis of drugs molecule design which was proposed in 1960.During the last 40 years,the CADD method has been widely applied as a burgeoning and potential research area.The aim of CADD is to design drug according to the pharmic model between the drugs and the enzyme or receptor which is applied the quantum mechanics,molecular dynamics,and quantitative structure-activity relationship.The CADD includes three methods:method basing on the ligand,method basing on the receptor,and combinatorial chemistry method.The CADD is a new technology to research drug which can accelerate the speed of drug design,economize the manpower and material resources.