Antioxidation properties of 4-morpholineacetonitrile chloride
Wei En · Zhongguo yaolixue tongbao · 2002
AIM To evaluate the effects of 4 morpholineacetonitrile chloride and related compounds on the oxidation of low density lipoprotein (LDL) METHODS The generation of conjugated dienes and thiobarbituric acid reactive substances (TBARS) in LDL and the relative electrophoretic mobility (REM) of LDL were measured during both copper induced and 2,2′ azobis (2 amidinopropane) dihydrochloride (AAPH) initiated oxidative system of LDL RESULTS During LDL oxidation, 4 morpholineacetonitrile chloride prolonged the lag phase of conjugated dienes formation, inhibited the output of TBARS in LDL, and decreased the REM of LDL in a concentration dependent manner CONCLUSION 4 morpholineacetonitrile chloride has inhibitory effect on oxidation of human LDL induced by Cu 2+ and AAPH in vitro .