Construction and Analysis for Molecular Interaction Network of Cell Adhesion
Wei Lie Xiao · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS · 2011
Complex network has been used to analyze the global and local properties of cell processes such as gene regulation,protein-protein interaction and signal transduction.A molecular network of integrin-mediated cell adhesions is constructed by data-mining and presented by a visualizing software.The network consists of 156 components linked by 690 interactions,with an average node degree of 8.66,an average cluster coefficient of 0.24 and an average path length of 2.6.Several functional modules are involved in switching on or off many of the molecular interactions within the network,consequently affecting cell adhesion,migration and cytoskeletal organization.Screening and examination of the adhesome network motifs reveals a relatively small number of key motifs,dominated by 3-nodes(three-component complexes).The role of the different network modules and modifs in regulating cell adhesions is also discussed.