Changes of Pulmonary Arterial Pressure and Cardiac Function of Healthy People before and after Short-term Exposure in Highland Areas
Xiao Shu-n · Medical & Pharmaceutical Journal of Chinese People's Liberation Army · 2014
Objective To discuss changes of pulmonary arterial pressure and cardiac function of the controls from plains before and after short-term exposure in highlands. Methods A total of 40 healthy people in plains with normal pulmonary arterial pressure and cardiac function from May to December 2013 were recruited in this study. and the values of Mean pulmonary artery pressure( mPAP),left ventricular ejection fraction( LVEF),right ventricular ejection fraction( RVEF),left and right ventricular Tei indexes were detected by ultrasonometry,and 6-min walking distance( 6-MWD) was also observed before and after exposure in highland for 10 d. Results After exposure in highland for 10 d,the values of 6-MWD,arterial oxygen saturation( SaO2) and RVEF were significantly lower,and values of mPAP,right ventricular Tei index were significantly higher compared with those before exposure( P 0. 05,P 0. 01),while the differences in values of LVEF and left ventricular Tei index were not statistically significant compared with those before entering the highland areas( P 0. 05). Conclusion Right ventricular function induced by hypoxia-induced pulmonary hypertension of healthy people in plains after short-term exposure in highlands may decrease,but there is no significant change in left ventricular function.