A quantitative analysis of the ultrastructures in pulmonary alveolar macrophages from the rats exposed to fenvalerate
Zhai Wei-lei · Zhongguo yaolixue yu dulixue zazhi · 1989
By using the stereological principles and methods,the ultrastructural changes in pulmonary alveolar macrophages from male Sprague-Dawley rats exposed to fenvalerate were quantitatively analysed.The main structural parameters include the volume density (Vv)of nucleus (Nu),cytoplasm (CP),mitochondria (Mi),lysosome (Ly),Golgi area (Go),rough and smooth surfaced endoplasmic reticula (RER,SER),and lipid droplet (LD); the surface density (Sv)and numerical density (Nv)of lipid droplet,lysosome,and mitochondrial outer membrane.The majorityof parameters revealed the apparent dose-dependent relationships and time-response characteristics.The results of present study at subcellular level provide a number of quantitative bases for the evaluation of the toxic effect of fenvalerate on pulmonary cells and for the elucidation of the mechanisms of lung injury as well as for the formulation of the hygienic criterion of fenvalerate.