Firing Patterns of Map-Based Neuron under Extracellular Alternating-Current Field
Xile Wei · Acta Biophysica Sinica · 2010
Different stimulus information is carried by various neural firing patterns.Based on the Map-based model, the impact of extracellular alternating-current (AC) field on the neural firing pattern was studied.Under the stimulus, neurons exhibit various firing patterns, including periodic bursting firing, periodic spiking firing, alternating firing and chaotic firing.Neurons are very sensitive to the change of stimulus frequency and amplitude.With the increase of stimulus frequency, a reverse period adding bifurcation scenario from bursting to spiking and chaotic firing was gained.A new alternating firing pattern was observed in the procedure of transitions between different periodic firing patterns.The behavior of the new firing pattern was an alteration of two periodic firing patterns.The series of the interspike interval (ISI) exhibited integer multiple characteristics.The frequency of electric field could influence intracellular and extracellular ionic oscillation period, causing the synchronization between neural firing behavior and stimulation signal, then it affected the firing patterns more obviously.The rules underlying the formation of various neural firing patterns inspired by extracellular alternating-current field were investigated.The research results suggested a functional role for the extracellular electric field in the excitability of biological nervous system and pathogenesis of several neurological diseases.