HMG-CoA Reductase Inhibitors-Study for Synthesis of Rosuvastatin Calcium
Dai Lian-hua · Guangzhou Chemical Industry · 2011
Starting with N-(5-((diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide(C28H29FN3O3PS),rosuvastatin calcium was prepared through condensation,hydrolysis and deprotection,esterification,hydrolysis,salting.The process was redesigned and the optimum technological conditions were investigated.Thus,the total yield reached 34.3%,HPLC purity 99%.The structure was determined by MS,CNMR and HNMR.The process exhibits simple,cost-efficient,high purity and yield,easy to scale up.