The association of gene polymorphism of α-adducin gene Gly460Trp with essential hypertension in Han nationality patients in Beijing
Jincheng Guo · Yixue yanjiusheng xuebao · 2005
Objective: To evaluate the association between gene polymorphism of α-adducin gene Gly460Trp and essential hypertension. Methods: Polymerase chain reaction was used to detect the polymorphism of α-adducin gene Gly460Trp in 348 hypertensive patients(EH) and 184 normotensive controls(NE) of Han Nationality in Beijing.Clinic blood pressure,24 h blood pressure,biochemical index were also detected. Results: There were no significant difference of α-adducin gene Gly460Trp polymorphism between EH and NE(P0.05).There were no significant difference of blood pressure between different genotypes of α-adducin gene Gly460Trp. Conclusion: There is no significant association of α-adducin gene Gly460Trp polymorphism with essential hypertension of the Han nationality of Beijing.