Improved Synthesis of Pitavastatin Calcium
Shan Ji-le · Fine Chemical Intermediates · 2014
Pitavastatin calcium is an important lipid regulator which is usually prepared by resolution of racemic or chiral synthesis. The authors have developed an improved process for the synthesis of pitavastatin calcium starting from 2-amino-4′-fluorobenzophenone in several steps in overall yield of 24.8%. The structure of the title compound was confirmed with IR and1H NMR spectra.