Research progress on discovery of drug potential toxicity and perspective on safety evaluation of Chinese materia medica
Yanjun Zhang · Zhongcaoyao · 2011
Following the development of science and technology,the number and variety of newly discovered compounds are increasing.However,it is a long process for the new compounds to become clinic medicines into the market eventually as well as be costly and difficult to manipulate with high failure rate.So it has been a hot point of modern pharmacy to set up a precise,fast,and sensitive model to evaluate the toxic effect of exogenous compounds on bio-organism.In recent years,large members of advanced biological methods and platforms for evaluating the drug toxicity have been put into use constantly.These methods not only overcome the shortcomings of traditional toxicology and lay the foundation for drug safety evaluation,but also save a lot of mannal labour,material resources,and financial resources.In this paper,we are going to review on the methods of drug toxicity predetermination and potential toxicity evaluation and also give an overlook of their application on the safety evaluation of CMM.