Antioxidative actions of diltiazem in patients with coronary disease
Fang Lü · 1997
AIM: To study the antioxidative effect of diltiazem in patients with coronary disease (CD). METHODS: Thirty CD patients (M 21, F 9, age 58±s 6 a) were given diltiazem 30 mg, po, tid for 4 wk and 30 healthy persons (M 18, F 12, age 58±9 a). RESULTS: Lipid peroxides (LPO), oxidized low density lipoprotein(oxLDL), spontaneous chemiluminescence (SCL), and luminol induced chemiluminescence (LCL) levels were decreased and glutathione peroxidase (GSH-Px) activies were increased after treatment compared with pretreatment P0.01. Elevations of the parameters showed no significant differences between treated patients and healthy persons (P0.05) except those of LCL. CONCLUSIONS: Diltiazem is a strong antioxidant.