Research progress in antimalarial mechanism and drug-resistant mechanism of artemisinin and its derivatives
Jingyan Wang · 2007
Artemisinin and its derivatives with endoperoxide function are new and important antimalarial drugs,and their antimalarial action is quick,efficient and without cross resistance.It is generally agreed that artemisinins' action mechanism is associated with the endoperoxide function,but some researchers have some other ideas.Up to the present,drugs like chloroquine,mefloquine and pyrimethamine have brought clearly drug resistance,and owing to the unique chemical constitution,artemisinins are the only drugs without drug resistance.So,finding their action mechanism is far important to avoid bringing the resistance and prolong their service life.