Design and development of a software program foridentification of ductal carcinoma in situ of the breast
Jie Gao · Chinese Journal of Stereology and Image Analysis · 2011
Objective The purpose of this study was to design a program for identification of ductal carcinoma in situ of the breast based on geometric parameters using quantitative image analysis,and test the ability of this program to identify breast ductal carcinoma in situ(DCIS).Methods Two hundred histological slides of ductal carcinoma in situ of the breast by routine HE staining were collected in this study.One hundred slides were used for design of the software program,and another 100 slides were used to test the software.Ductal carcinoma in situ with cribriform architecture was a main focus of this study,and quantitative parameters including perimeter,diameter,area,distance,ratio of the distance,and average gray scale were used as geometric parameters for the program design for DCIS detection.Results This program analyzes the selected region of interest,and used interactive image segmentation for calculation of parameters including perimeter,diameter,area,distance,ratio of the distance,and average gray scale.This software can also export and save these measurement data and the results of analysis.In the test of this software with 100 slides,the diagnostic accuracy was 98%.Conclusion We concluded that this image analysis program has potential as a diagnostic tool for identification of DCIS.