Progress in Research of Multi-target Drugs and Their Molecular Design
Xinqiang Yin · Yaoxue jinzhan · 2011
The origin of the some diseases is ascribed to the altering of gene expression caused by multiple factors.When used in these diseases,the single-target drugs usually exert unsatisfying therapeutic effects or have severe toxicity,while the multi-target drugs give satisfactory therapeutic effects due to their acting multiple nodes of the human disease network and simultaneously produce synergistic effect of the targets.Therefore the multi-target drugs may be used to treat complex disease systems such as tumor,nervous system,diabetes,high blood pressure and AIDS.This review summarized the classification,characteristics,design strategies and molecular models of the multi-target drugs.