The Effect of Piper Hancei Extract on the Atherosclerosis of Rabbits
Jian Cao · Zhongguo yaofang · 2005
OBJECTIVE:To observe the effect of Pipers hancei extract on the atherosclerosis of rabbits fed with high lipid food and to discuss its mechanism of action.METHODS:The rabbits were divided into high lipid group,Pipers hancei groups (high,medium and low dose groups),which were fed with high lipid food for 3 weeks before administered with medicine or normal saline,12 weeks later,the blood lipid,pathological changes of aortic plaque and lesion of coronary artery,serum superoxide dismutase (SOD)activity and serum malondialdehyde (MDA)activity were determined,in which a control group was established.RESULTS:Compared with the high lipid group,the levels of serum total cholesterol (TC),triglycerides (TG)and low density lipoprotein (LDL)have been significantly decreased for the high dose Pipers hancei group(P0.05),degree of pathological changes of aortic plaque and lesion of coronary artery has been significantly lowed in both the high and low dose groups(P0.05),and serum SOD activity has been increased while serum MDA has been decreased(P0.05).CONCLUSION:Piper hancei extract can significantly reduce the degree of pathological changes of the atherosclerosis of rabbits and which has a good antioxidation and certain regulatory ability on serum lipid.