The Synthesis of Rosuvastatin Side Chain
Kong Ye-qin · Zhejiang Chemical Industry · 2014
Rosuvastatin side chains-(3R) t-butyldimethylsilyloxy-6-dimethoxy-naphthalene acyl-5-oxo-hexanoic acid tert-butyl ester was synthesized through condensation, reduction, transesterification, esterification and transesterification using 3-tert-butyldimethylsilyloxy glutaric anhydride and(S) 2-hydroxy-2-phenyl-acetic acid benzyl ester as raw materials.