Association of gene polymorphism of cholesteryl ester transfer protein with type 2 diabetes
Yueming Zhang · Chinese Journal of Public Health · 2009
Objective To study the association of TaqⅠ gene polymorphism with type 2 diabetes and lipodogramme in Uygur people.Methods On basis of case-control design,lipodogramme of Uygur people was determined by automatic biochemical analyzer technology and the polymorphism of cholesteryl ester transfer protein(CETP) was analyzed by PCR-RFLP in 53 type 2 diabetes mellitus(T2DM) patients,53 patients with impaired glucose tolerance(IGT) and 106 normal control of Uygur nationality.Results The fasting plasma glucose(FPG) in normal group was 5.14±0.24 mmol/L,10.79±3.34 mmol/L in T2DM group,and 5.97±0.41 mmol/L in IGT group(F=205.87,P=0.000),respectively.CETP geno-type distribution was significant different between the three groups(P=0.028).The frequency of H+H-genotype for T2DM was significantly higher than that of others(69.8%,45.3%,41.5% for T2DM,IGT,and normal group,respectively).The values of FPG was 6.04±1.72 mmol/L for subjects with H-H-genotype,6.03±1.63 mmol/L with H+H+,and 7.48±3.60 mmol/L with H+H-,respectively,with significant difference between the groups(P=0.001).The results of logistic regression showed that the dependent risk factors of T2DM were total glucose(P=0.000),CETP genotype(P=0.007),waist circumference(P=0.048).The subjects with H+H-had a 4.042 folds(95%CI=1.243-13.149,P=0.020) risk of T2DM compared with subjects with H-H-genotype.Conclusion CETP gene TaqⅠ polymorphism is closely related to the risk of T2DM and the H+H-genotype may serve as a genetic risk factor of T2DM among Uygur people.