Advance in search for gene polymorphisms on pharmacokinetics of atorvastatin
Yong Lai · Chinese Journal of New Drugs and Clinical Remedies · 2012
Atorvastatin is the most commonly used blood lipid medication,which can significantly reduce the plasma low-density lipoprotein cholesterol levels and prevent cardiovascular diseases.But for different individuals,the efficacies of atorvastatin are very different.The studies had shown that gene polymorphisms were the important factors led to diversity of pharmacokinetics in different individuals.The pharmacokinetic characteristics of atorvastatin and its gene polymorphisms were reviewed in this paper to supply some advices for the individual use of atorvastatin in clinic.