Relative bioavailability of effervescent tablet of aspirin-vitamin C in healthy volunteers
Limei Zhao · Zhōnghuá yàoxué zázhì · 2004
OBJECTIVE To study the pharmacokinetics of aspirin-vitamin C effervescent tablet and compare the relative bioavailability of the preparation. To explore the method for studying the extent of absorption and bioequivalence of endogenous non-stable substances. METHODS In this randomizd crossover designed study, single doses of aspirin and vitamin C in two preparations were given to 18 healthy male volunteers . The plasma concentrations of salicylic acid and vitamin C were determined by HPLC. RESULTS The pharmacokinetic parameters of salicylic acid and vitamin C for the test preparation and reference preparation were assessed as follows: For salicylic acid, cmax were (54.8±15.4) and (64.9±17.8 )ug.mL-1, t1/2(2.8± 1.0) and (3.3±0.9)h, AUC0-24 were (307.2± 112.8) and (362.5± 129.8)(ug.h.mL-1, respectively. For vitamin C, cmax were (6.3± 2.2) and (7.4± 2.5)ug.mL-1, AUC0-12 (50.7± 18.6) and (57.9± 19.3)ug. h. mL-1 , respectively. The relative bioavailability of salicylic acid and vitamin C in test preparations were ( 105.5 ± 26.1) % and ( 107.1±28.7) %, respectively. CONCLUSION The two preparations were of bioequivalence.