Research Advances in Mechanism of Flavonoids against Atherosclerosis
Ying Zhang · Tianran chanwu yanjiu yu kaifa · 2012
Atherosclerosis leads to various problems including coronary artery heart disease and stroke which seriously threats to health.The oxidative modification of low density lipoprotein-cholesterol(LDL-c) is considered to be a key factor to atherosclerosis in early lesion.Antioxidants,such as flavonoids,thus become potential anti-atherosclerosis agents for their function as excellent oxygen free radical scavengers and lipoprotein oxidation inhibitors.They prevent LDL-c from oxidative modification and decrease oxidative stress through the following mechanisms:Free-radical scavenging,metal ions chelating,endogenous antioxidant protection and cellular antioxidant modification.The pathogenesis of atherosclerosis is accompanied by inflammation and flavonoids have the ability to work against inflammation and platelet aggregation.There are some quantitative structure-activity relationships(QSAR) about different types of flavonoids to atherosclerosis.This paper summarized the advances in the mechanisms of flavonoids against atherosclerosis.