Association Between Familial Combined Hyperlipidemia(FCHL) and Apolipoprotein E Polymorphism
Yanhong Zhang · Chinese Journal of Hypertension · 2004
Objective Familial combined hyperlipidemia(FCHL) is the most common hyperlipidemic disorder with a frequency of 10%～20% in myocardial infarction survivors. The present study is to investigate the relation between FCHL and apoE polymorphism. Methods The apoE gene polymorphism and allele frequencies were detected using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in subjects with FCHL (n160) and individuals without dyslipidemia as control group (n328). Results The frequency distribution of apoE genotypes of e2 e2, e2 e3, e2 e4, e3 e3, e3 e4, e4 e4 was 0, 0.081, 0.031, 0.712, 0.138 and 0.038 in FCHL group, and 0, 0.168, 0.024, 0.686, 0.116 and 0.006 in control group. The alleles frequency of e2, e3 and e4 were 0.056, 0.822 and 0.122 in FCHL patients, compared with control group of 0.096,0.828 and 0.076, respectively. Significant differences in the distribution of apoE genotypes and alleles between FCHL and control groupsχ212.94, P0.012; χ29.03, P0.011 was found. Conclusion This study suggests that apoE polymorphism may be one of the genetic susceptible factors affecting the complex FCHL phenotype. ApoE allele e4 is in association with the lipid phenotype of FCHL.