Influence of Chemical Structures and Physicochemical Properties of Statins on Their Pharmacodynamics and Pharmacokinetics
Tao Tao · Chinese Journal of Pharmaceuticals · 2012
Statins can safely and effectively reduce the plasma level of low-density lipoprotein cholesterol(LDL-C),so that they are drugs of choice for the treatment of hypercholesterolemia.All approved statins share a common mechanism of action but their chemical structures are different.The chemical structures govern their water solubility and lipophilicity,which in turn affect their absorption,distribution,metabolism and excretion.The influences of the chemical structures and physicochemical properties of statins on their pharmacodynamics and pharmacokinetics are reviewed in this paper.All statins have hepatic first pass effects so that they can be enriched in liver.Among the approved statins,rosuvastatin has the stronger effect on reducing LDL-C level,followed by atorvastatin,simvastatin and pravastatin.