The Impact of Drug Metabolism in Contemporary Drug Discovery: New Opportunities and Challenges for Mass Spectrometry
Thomas A. Baillie, Paul G. Pearson · Humana Press eBooks · 2000
Current developments in contemporary drug discovery techniques offer the potential to discover and develop new chemical entities to treat a spectrum of diseases or medical conditions for which either no current therapies exist, or for which existing therapies are inadequate. In particular, advances in synthetic medicinal chemistry (i. e., combinatorial chemistry and rapid analog synthesis), the availability of new molecular targets derived from genomics-based discovery, and high-throughput screening technology have the potential to identify new chemical entities (NCEs) with potent and selective pharmacological properties. To realize the full potential of these techniques, it is absolutely essential that a contemporary pharmacokinetics and drug metabolism program be implemented as a fully-integrated component of the drug-discovery process. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.