Preparation and in vitro / in vivo Evaluation of Lovastatin Sustained-release Tablets
Yu Lu · Chinese Journal of Pharmaceuticals · 2006
Lovastatin sustained-release tablets were prepared using HPMC as excipient. The in vitro release profile was evaluated and compared with ALTOCOR. The results showed that in vitro release profiles of the two products were similar during the initial 8h. The single dose and multi-dose pharmacokinetics of the prepared tablets were investigated in eighteen healthy male volunteers, with lovastatin tablets as reference. The result showed that the relative bioavailability were (145.83±24.47)% and (144.97±18.63)%, respectively.