An experimental study of simvastatin inhibiting the relapse distance after orthodontic tooth movement
Hou Jian-hua · Journal of Modern Stomatology · 2006
Objective To investigate the effects of systematic administration of simvastatin solution on the relapse distance after the tooth movement.Methods Orthodontic tooth movement of upper first molar was performed in 32 rats with coil spring for 21 days. Thirty-two rats were randomly allocated into 4 groups: Three simvastatin groups( 2.5mg/kg, 5.0mg/kg and 10.0mg/kg) and the control group.The experimental groups were administered simvastatin daily at 1 day before appliances removed.The control group received the isotonic saline instead. Four weeks later all animals were deeply anesthetized and killed. The interdental distance between the first and second maxillary molars was measured, separately when appliances were removed after 1 week, 4 weeks. At the same time, weight of rat was measured.Results ①Simvastatin had no significant influence on the body weights(P 0.05). ②Between experimental groups and the control group,the total amount of relapse,the anteriors were lower than the latter(P 0.05); and the percentage of relapse,the anteriors were significantly lower than the latter (P 0.01). The lower dose, the less extent relapsed. In the low-dose group,the percentage of relapse was the lowest in experimental groups.Conclusion The study indicates that a single systemic administration of simvastatin decreases the extent of initial relapse in experimentally moved rat molars,especially low-dose simvastatin has more significantly effect.