Effect of aprotinin on hemorrhage、blood requirement after the treatment of obstetrics DIC
Weng Xiuqi · Clinical Medicine · 2007
Objective To study the effect of aprotinin on hemorrhage,blood requirement and blood coagulative function after the treatment of obstetrics DIC.Methods 25 patients with obstetrics DIC were divided randomly into two groups:aprotinin group(group A) and conventional group(group B).Group A:100 KIU aprotinin with 250 ml saline were infused.Group B:equal volume of saline were infused.Other salvage treatment was homology in two groups.The volume of blood loss,fresh blood plasma and allogenic RBC requirement,changes of Hb levels,hematocrit,platelet counts,prothrombin time,activated partial thromboplastinogen time(APTT) and plasma fibrinogen content were recorded and compared between two groups.Results The average blood loss,fresh blood plasma and allogenic RBC requirement in group A were significantly lower than group B(P 0.01).The duration for PT,APTT,FIB,PLT resuming to normal in group A was shorter than group B.Conclusion Aprotinin used in obstetrics DIC can reduce hemorrhage and blood requirement.The parameters of coagulative function resuming to normal are quicker when using aprotinin in obstetrics DIC.