Irbesartan-antihypertensive Drug of Angiotension II Receptor Antagonist
Sun S. Lu · The Chinese Journal of Clinical Pharmacology · 2000
Renin-Angiotensin-System(RAS) exhibits a key role in the pathogenesis ofhypertension. Angiotensin converting enzyme(ACE) inhibitor reduced the formation ofangiotension-Ⅱ of RAS, and it also induces some adverse effects such as coughing, whichthe patient could not tolerate. Angiotensin-Ⅱ receptor antagonist is a new kind ofantihypertensive drug. It directly inhibited angiotension Ⅱ AT1 receptor, and itsantihypertension was effective and safe, and it had lower adverse effects. In this article, forone of the new angiotensin-Ⅱ-irbesartan drugs, we summarized the pre-clinical-basic study,the pharmacodynamics and pharmacokinetics study in the volunteers, and the effect andsafety for mild, and moderate hypertension.