Mitogen-activated protein kinases and morphine tolerance
Guowei Lü · Basic & Clinical Medicine · 2010
The MAPKs activation pathway consists of three protein kinases in activation sequence:MAPKs kinase kinases (MKKKs) →MAPKs kinases (MKKs) →MAPKs and four pathways:extracellular signal-regulated kinase (MAPKERK),C-JUN N-terminal kinase (MAPKJNK),MAPKP38 and MKK5/MAPKERK5 activation pathways.It has been proved that MAPKs(ERK,JNK and P38) are acvtivated in the progress of morphine tolerance.Inhibitors of any element of MAPKs activation pathway may function as a potential clinical medicine for morphine tolerance.