An approach for the analysis of pharmacodynamic interactions and the simulation of combined response
Ling Xu · Zhongguo yaolixue tongbao · 2007
Aim An approach is set up to study pharmacodynamic interaction and simulate the combined response.Methods An orthogonal design with 1-level=used and 2-level=not used,was selected from L8(23),L8(24),L12(25) and L12(26),and the two one-sided t tests was used to analyze the importance of component and its effectiveness.Some mathematical models were proposed to analyze drug interactions and to predict the combined response.The bias was evaluated by the both scatter plots.An example of the compound with six components was applied to evaluate this approach.Results This approach determined each component performance by its contribution to combined response,which showed the importance of a component in combination.Drug interactions were evaluated among the combinations in each group.The prediction model performed well and simulated the combined response in the different of components in combination.Conclusion The approach can provide more information about pharmacodynamic interactions than that from the analysis of variance,especially in clinical study and the compounds of more than 3 components.