Dynamic change and influencing factors of glomerular filtration rate in type 2 diabetes
Hao Dai · Linchuang huicui · 2009
Objective To observe dynamic change and influencing factors of glomerular filtration rate(GFR) in type 2 diabetes.Methods 309 type 2 diabetic patients in 1994-2008 were divided into three groups according to diabetes duration of last GFR:groupⅠ(diabetes duration ≤10 years,n=76);groupⅡ(diabetes duration 10-20 years,n=139);group Ⅲ(diabetes duration 20 years,n=94).Last GFR and clinical characteristics were compared;baseline GFR,last GFR and the rate of GFR decline in type 2 diabetes with hypertension were compared,too.The rate of GFR decline was calculated.Results With age and diabetes duration increasing,baseline GFR and last GFR of group Ⅲ were more evidently decreased than those of groupⅠand groupⅡ,baseline GFR:group Ⅰ was(73.5±26.8) ml/min,group Ⅱ was(71.6±22.0) ml/min,group Ⅲ was(63.0±21.3) ml/min,last GFR:group Ⅰ was(67.5±27.7) ml/min,group Ⅱ was(61.6±24.8) ml/min,group Ⅲ was(47.0±23.4) ml/min(P0.01).The average yearly rate of GFR decline of group Ⅰ was(3.6±10.4) ml/min,group Ⅱ was(2.7±7.8) ml/min,group Ⅲ was(4.6±7.4) ml/min(P0.05).Compared with baseline GFR and last GFR,type 2 diabetes patients with hypertension were more evidently decreased than type 2 diabetes ones without hypertension.In groups of type 2 diabetes without hypertension,baseline GFR:group Ⅰ was(87.9±18.5) ml/min,group Ⅱ was(80.2±19.1) ml/min,group Ⅲ was(79.3±19.0) ml/min,last GFR:group Ⅰ was(85.0±22.5) ml/min,group Ⅱ was(75.0±18.7) ml/min,group Ⅲ was(68.6±17.0) ml/min.In groups of type 2 diabetes with hypertension,baseline GFR:group Ⅰ was(66.0±18.0) ml/min,group Ⅱ was(68.1±22.2) ml/min,group Ⅲ was(59.2±20.1) ml/min.last GFR:group Ⅰ was(58.4±25.9) ml/min,group Ⅱ was(56.2±25.0) ml/min,group Ⅲ was(41.9±21.8) ml/min(P0.01),but the yearly rate of GFR decline was no significant difference between with the patients hypertension or without hypertension(P0.05).Conclusion Age and diabetes duration are important dangerous factors to diabetic nephropathy,GFR is more significantly decreased in diabetes duration 20 years.GFR is more significantly decreased for type 2 diabetes with hypertension.