Current trends in label-free technologies
Philip B. Rawlins · 2010
Label-free technologies have been used throughout drug discovery for the detection and characterisation of molecular interactions. The implementation of automated systems, increased sensitivity and the development of new technologies have recently broadened the use of label-free methods from primary screening through to mechanism-of-action studies in lead optimisation. The trend is now towards adopting label-free methods earlier in the drug discovery process so that compounds can be tested against native protein or cells resulting in improved biological assessment of compounds more predictive of therapeutic effect.