Effect of atorvastatin calcium on High-sensitivity C-reactive Protein and N-terminal proBNP in Esstential Hypertensive Patients
Duan Shiyin · 2013
Objective To investigate the effect of atorvastatin calcium on serum high-sensitivity C-reactive protein( hs-CRP)and N-terminal proBNP(NT-proBNP) in hypertensive patients. Methods After two weeks of single blind placebo period,88 hypertensive patients were divided into experimental group(atorvastatin calcium 20 mg, once per night,nifedipine controlled-release tablets 30 mg,once per day) and control group(nifedipine controlled-release tablets 30 mg,once per day)for eight weeks for both groups. The level of NT-proBNP and hs-CRP were evaluated before and the end of treatment. Results SBP and DBP were significantly reduced in two groups after treatment(P 0.01). In experimental group,the level of hs-CRP, NT-proBNP were significantly decreased after treatment(P 0.01).In control group,the level of hs-CRP were no significant differences after treatment(P0.05). Conclusion Atorvastatin calcium can Further reduce hs-CRP and NT-proBNP in hypertensive patients.