Inhibitive Effect of Iressa on Angiogenesis in LCI-D20 Orthotopically Implanted High Metastatic Human Hepatocellular Carcinoma Model
Qiong Xue · Bulletin of Chinese Cancer · 2006
[Purpose] To explore the inhibitive effect of Iressa on angiogenesis of highly metastatic human hepatocellular carcinoma model of LCI-D20.[Methods] Twelve nude mouse via orthotopic implantation of LCI-D20 were randomized into two groups:control group(A group)and Iressa group(B group).Tumor mass and microvessel density(MVD)were measured at the 28th-day of treatment.[Results] The mean tumor mass were 2.01g and 1.18g in A and B group respectively.The mean MVD were 39.57/HP and 14.10/HP in A and B group respectively.There was significant difference between two groups(P0.05).[Conclusion] Iressa inhibits the growth of tumor and angiogenesis of hepatocellular carcinoma.