Changes in plasma Pselectin level and interventions for lipid lowering in patients with unstable angina pectoris
Sun Decheng · Zhonghua weizhongbing jijiu yixue · 2001
Objective:To study the relationship between plasma Pselectin and coronary arteriosclerotic lesions and the effects of intervention lipid lowering in the patients with unstable angina pectoris.Methods:The plasma Pselectin and oxidized low density lipoprotein (OXLDL) were measured by enzymelinked immunosorbent assay (ELISA) and serum nitric oxide (NO) was measured by colorimetric analysis method before and after treatment with simvastatin in 62 patients with unstable angina pectoris and 30 healthy controls.Results:(1) The patients with unstable angina pectoris had higher levels of plasma Pselectin and OXLDL,lower levels of serum NO compared with those of control subjects.(2) A direct positive correlation was observed between plasma Pselectin and OXLDL levels and a direct negative correlation between plasma Pselectin and NO levels in patients with unstable angina pectoris.(3) Administration of simvastatin (20 mg/d for 6 weeks) to patients with unstable angina pectoris significantly reduced plasma Pselection and OXLDL levels and significantly elevated serum NO level.Conclusions:The patients with unstable angina pectoris do have inflammatory reaction due to coronary arterisclerotic lesions.The development of the disease is closely related to plasma Pselection,OXLDL and serum NO levels,and it can be blocked by intervention therapy for lipid lowering.